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Plant sources of anti-cancer agents : ウィキペディア英語版 | Plant sources of anti-cancer agents
Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or prevention of cancer in humans. ==Background== In the 1950s, scientists began systematically examining natural organisms as a source of useful anti-cancer substances.〔 It has recently been argued that "the use of natural products has been the single most successful strategy in the discovery of novel medicines". Plants need to defend themselves from attack by micro-organisms, in particular fungi, and they do this by producing anti-fungal chemicals that are toxic to fungi. Because fungal and human cells are similar at a biochemical level it is often the case that chemical compounds intended for plant defence have an inhibitory effect on human cells, including human cancer cells.〔http://www.ncbi.nlm.nih.gov/pmc/articles/PMC88926/〕 Those plant chemicals that are selectively more toxic to cancer cells than normal cells have been discovered in screening programs and developed as chemotherapy drugs〔http://www.acs.org/content/acs/en/education/whatischemistry/landmarks/camptothecintaxol.html〕
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